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Drug: Ciprofloxacin

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Total 5423 results found since Jan 2013.

The search of potential inhibitors of the AcrAB-TolC system of multidrug-resistant Escherichia coli: an in silico approach.
Abstract The number of infections caused by multidrug antibiotic resistance (MDR) species is increasing globally. The efflux pump system, AcrAB-TolC, confers Escherichia coli resistance to many antibiotics and results in poor treatment outcomes. Different rational drug design techniques were employed to search for a safe and effective AcrAB-TolC system inhibitor. Ligand docking was performed to analyze the binding of different ArcB substrates and/or inhibitors in the different AcrAB crystal structure binding sites. The validated docking site using the established docking preferences was used to perform virtual hig...
Source: Applied Microbiology and Biotechnology - June 16, 2019 Category: Microbiology Authors: Abdel-Halim H, Al Dajani A, Abdelhalim A, Abdelmalek S Tags: Appl Microbiol Biotechnol Source Type: research

Evaluation of the anti-infectious properties of polyester vascular prostheses functionalised with cyclodextrin
This study aimed to evaluate the efficacy of PVP-CD loaded with antibiotics against bacteria that are commonly responsible for SVGI in current practice.Methods: Samples of PVP-CD loaded with antibiotics and uncoated-PVP were tested in-vitro for their ability to limit bacterial adhesion and prevent bacterial proliferation over time. Their anti-infectious properties were further evaluated in-vivo in a mouse model of SVGI. Both Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, MRSA) and Gram-negative (Escherichia coli, En. cloacae and Pseudomonas aeruginosa) bacteria were tested.Results: PVP-CD loaded with rif...
Source: Journal of Infection - October 17, 2013 Category: Infectious Diseases Authors: Elixène Jean-Baptiste, Nicolas Blanchemain, Christel Neut, Feng Chai, Mickael Maton, Bernard Martel, Hartmut Hildebrand, Stéphan Haulon Tags: Infectious Disease Practice Source Type: research

Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.
Abstract A series of 1,2,4-triazole-based compounds was designed as potential antibacterial agents using molecular hybridization approach. The target compounds (23-44) were synthesized by Mannich reaction of 1,2,4-triazole-3-thione derivatives with ciprofloxacin (CPX) and formaldehyde. Their potent antibacterial effect on Gram-positive bacteria was accompanied by similarly strong activity against Gram-negative strains. The toxicity of the CPX-triazole hybrids for bacterial cells was even up to 18930 times higher than the toxicity for human cells. The results of enzymatic studies showed that the antibacterial activ...
Source: European Journal of Medicinal Chemistry - April 29, 2015 Category: Chemistry Authors: Plech T, Kaproń B, Paneth A, Kosikowska U, Malm A, Strzelczyk A, Stączek P, Świątek Ł, Rajtar B, Polz-Dacewicz M Tags: Eur J Med Chem Source Type: research

Topological pattern for the search of new active drugs against methicillin resistant Staphylococcus aureus.
Abstract Molecular topology was used to develop a mathematical model capable of classifying compounds according to antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). Topological indices were used as structural descriptors and their relation to antimicrobial activity was determined by using linear discriminant analysis. This topological model establishes new structure activity relationships which show that the presence of cyclopropyl, chlorine and ramification pairs at a distance of two bonds favor this activity, while the presence of tertiary amines decreases it. This model was appl...
Source: European Journal of Medicinal Chemistry - July 8, 2017 Category: Chemistry Authors: Bueso-Bordils JI, Perez-Gracia MT, Suay-Garcia B, Duart MJ, Martin Algarra RV, Lahuerta Zamora L, Anton-Fos GM, Aleman Lopez PA Tags: Eur J Med Chem Source Type: research

From quinoline to quinazoline-based S. aureus NorA efflux pump inhibitors by coupling focused scaffold hopping approach and pharmacophore search
ChemMedChem. 2021 May 25. doi: 10.1002/cmdc.202100282. Online ahead of print.ABSTRACTAntibiotic resistance breakers, such as efflux pump inhibitors (EPIs), represent a powerful alternative to the development of new antimicrobials. Recently, by using previously described EPIs, we developed pharmacophore models able to identify inhibitors of NorA, the most studied efflux pump of the Staphylococcus aureus. Herein, we reported a pharmacophore-based virtual screening of a library of new potential NorA EPIs generated by an in-silico scaffold hopping approach of the quinoline core. After chemical synthesis and biological evaluati...
Source: ChemMedChem - May 25, 2021 Category: Chemistry Authors: Nicholas Cedraro Rolando Cannalire Andrea Astolfi Gianmarco Mangiaterra Tommaso Felicetti Salvatore Vaiasicca Giada Cernicchi Serena Massari Giuseppe Manfroni Oriana Tabarrini Violetta Cecchetti Maria Letizia Barreca Francesca Biavasco Stefano Sabatini Source Type: research

Search for a Shared Genetic or Biochemical Basis for Biofilm Tolerance to Antibiotics across Bacterial Species
Antimicrob Agents Chemother. 2022 Mar 10:e0002122. doi: 10.1128/aac.00021-22. Online ahead of print.ABSTRACTIs there a universal genetically programmed defense providing tolerance to antibiotics when bacteria grow as biofilms? A comparison between biofilms of three different bacterial species by transcriptomic and metabolomic approaches uncovered no evidence of one. Single-species biofilms of three bacterial species (Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii) were grown in vitro for 3 days and then challenged with respective antibiotics (ciprofloxacin, daptomycin, and tigecycline) for an ad...
Source: Antimicrobial Agents and Chemotherapy - March 10, 2022 Category: Microbiology Authors: Philip S Stewart Kerry S Williamson Laura Boegli Timothy Hamerly Ben White Liam Scott Xiao Hu Brendan M Mumey Michael J Franklin Brian Bothner Francisco G Vital-Lopez Anders Wallqvist Garth A James Source Type: research

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research

Gram-negative bacteraemia in haemodialysis
Conclusions CVCs and diabetic foot ulcers remain significant risk factors for Gram-negative bacteraemia, highlighting the importance of vascular access planning. Despite good levels of antibiotic sensitivity, the early mortality following Gram-negative bacteraemia remains high, supporting aggressive treatment of such pathogens.
Source: Nephrology Dialysis Transplantation - June 22, 2015 Category: Urology & Nephrology Authors: Murray, E. C., Marek, A., Thomson, P. C., Coia, J. E. Tags: Intra- and extracorporeal treatments of kidney failure Source Type: research

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research

Urinary infection in patients of public health care of Campo Mourão-PR, Brazil: bacterial prevalence and sensitivity profile
Conclusion: The rate of microbial resistance has risen, showing the need for a more effective control of antimicrobial use. Introdução: Os casos de resistência bacteriana nas infecções do trato urinário (ITUs) vêm aumentando significativamente, principalmente devido ao uso indiscriminado de antimicrobianos. Objetivo: Avaliar a prevalência e o perfil de sensibilidade aos antimicrobianos dos microrganismos isolados nas uroculturas de pacientes atendidos no Laboratório de Análises Clínicas Consórcio Intermunicipal de Saúde da Comunidade dos Municípios da Região de Campo Mourão (CIS-COMCAM). Método: Fez-se um...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 14, 2014 Category: Pathology Source Type: research

Use of Eculizumab in atypical hemolytic uremic syndrome after renal transplantation.
Authors: Teixeira CI, Mota RG, Afonso BG, Carneiro TV, Meira GS, Mendonça DU Abstract To report the use of Eculizumab in atypical hemolytic uremic syndrome (aHUS) after renal transplantation. A 16 year-old patient diagnosed with chronic kidney disease since 2010, due to aHUS, under dialysis. kidney transplantation by deceased donor: February/2012. She showed good clinical evolution until the 14th postoperative day, when he developed a fever, oliguria, worsening of renal function [serum creatinine (CRs): 4.0 mg/dl] and signs of hemolysis [platelets: 110,000 mm3; hemoglobin (Hb): 4.5 g/dL; LDH: 3366 U/L]. Renal biop...
Source: Jornal Brasileiro de Nefrologia - December 21, 2015 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research